CPSA Metabolomics 2018

Meeting Program

Updated March 8, 2018

Sunday March 18  Pre-Conference Events

4:30 pm

Hilton Conference Center Courtyard

EVENT

CPSA 5K

Kick off the week with the CPSA 5K (it's a walk in the park!) Join friends and colleagues for a leisurely walk, jog, or run through the beautiful UF campus and all for a good cause!

Sign up online - Free!

Organizers: Timothy Garrett, University of Florida; Nicole Matz, PRA Health Sciences; Michelle Reid, University of Florida; Martin Steel, McKinley Scientific; Shane Needham, Alturas Analytics

"Together We Can Go Farther"

Monday March 19  Pre-Conference Event & Workshop

9:00 am

Mark Bostick Golf Course
UF Campus

EVENT

CPSA OPEN

Join in for a fun walk in the sun. Begin your day at CPSA with a round of golf with friends and colleagues at the Mark Bostick Golf Course on the beautiful UF Campus. All skill levels welcome!

Organizers: Paul Corcoran, McKinley Scientific and Steve Fannin, Bruker Daltonics

Sign up to join in on the fun!

1:00 pm - 4:00 pm

UF Clinical & Translational Science Institute
3rd Floor

Workshop

Newborns Have Grown Up to be Adolescents in Terms of Screening: The Next Stage of Metabolomics is Here!

Don Chace, Medolac Laboratories
Mike Lee, Milestone Development Services

Advances in metabolomics drive a parallel surge in metabolite discovery – and inspire new platforms able to measure increasing numbers of compounds in blood, plasma or urine (see the birth of MS/MS Screening). Our ability to perform such analyses at the microsample scale – a single drop of blood dried on filter paper – has given rise to modern newborn screening. This workshop will provide an updated perspective on the current revolution in metabolomics and clinical diagnostics - and how this movment started with the analysis of amino acids and acylcarnitines 20 years ago. It is also why we could learn a lot from newborn screening where the analysis is only a small piece of the puzzle. Quality systems from the specimen to an actionable and clear report to a clinician are key to success and validation. Analytical Quality and References systems are key to achieving this validation and confidence in this stage of this rapid growth phase for metabolomics, or rather its adolescent period. Or for a more simple statement, metabolomics need rules and references, as do teenagers!

There is no workshop registration fee for CPSA Metabolomics attendees.

5:00 pm - 7:00 pm

UF Clinical & Translational Science Institute
3rd Floor

Welcome Reception & Metabolomics Lecture Series

Annotating the Metabolome: Spectral Complexity and the Potential Benefits of Low Flow Separations Coupled to Electrospray

Patrick Brophy, Ph.D.
Senior Scientist, Separations Research
Waters Corporation

Tuesday March 20

7:30 am - 8:30 am

UF Clinical & Translational Science Institute
3rd Floor

Good Morning

Registration & Coffee

8:30 AM - 9:00 AM

UF Clinical & Translational Science Institute
3rd Floor

Welcome & Opening Remarks

Mike Lee

Welcome
Mike Lee
Milestone Development Services

Tim Garrett

Format, Objectives, Opening Remarks
Tim Garrett
University of Florida

9:00 AM - 9:45 am

UF Clinical & Translational Science Institute
3rd Floor

Plenary Lecture

Alla Kloss

Applied Metabolomics: The Way to Reduce Element of Surprise in Pharmaceutical Industry

Alla Kloss, Sanofi

10:00 am - 11:30 am

UF Clinical & Translational Science Institute
3rd Floor

Symposium Session

Cancer Metabolism

Discussion Leader: John Koomen, H. Lee Moffitt Cancer Center and Research Institute

Acetyl-CoA Carboxylase 1 is a Metabolic Vulnerability for MYC-driven Lymphoma
Kristen E.N. Scott, H. Lee Moffitt Cancer Center and Research Institute

Cysteine Dioxygenase is a Metabolic Liability for Non-Small Cell Lung Cancers
Gina DeNicola, H. Lee Moffitt Cancer Center and Research Institute

Quantitative Proteomics for Measuring Correlates in a Melanoma Clinical Trial
Lancia N.F. Darville-Bowleg, H. Lee Moffitt Cancer Center and Research Institute

11:45 am - 1:15 pm

UF Clinical & Translational Science Institute
3rd Floor

Lunch, Vendor Spotlight & Poster Review

Detecting Metabolomic Signatures in Urine from Renal Cell Carcinoma Patients

David Gaul, Georgia Institute of Technology

Lunch served in lobby. Join the session, then mix and mingle with our vendors and poster authors

1:30 pm - 3:00 pm

UF Clinical & Translational Science Institute
3rd Floor

Symposium Session

Personalized Metabolism

Discussion Leaders: Don Chace, Medolac Laboratories and Emily Ehrenfeld, New Objective

Metabolomics: The Symphony of Life or the Cacophony of Failure (Challenges with Multi-Analyte Panels)
Tim Garrett, University of Florida

Name that Tune (Disease) From Simply B-flat to Scaled-Up!
Don Chace, Medolac Laboratories

Harmonization of Laboratories MS/MS Analyte Results Using the CDC Quality Control Materials
Konstantinos Petritis, Centers for Disease Control and Prevention

3:15 pm - 4:45 pm

UF Clinical & Translational Science Institute
3rd Floor

Symposium Session

Emerging Technologies

Discussion Leader: Dave Pirman, Agios Pharmaceuticals

Characterizing Models of Metabolic Disease: Contrasting Plasma Metabolomics vs Flux Analyses
Steve Previs, Merck

Weight-Independent Measurements of Modified Amino Acids in Tumor Tissue by LC-MS/MS: Comparisons Between FFPE and Frozen Samples
Max Lein, Agios

Using Local Perturbations to Dissect Metabolism of Cancer and Immune Cells in Tumors
Shawn Davidson, Brigham and Women’s Hospital, Harvard

6:00 pm

McKethan Stadum
UF Campus

Sponsored Socail Event

Play Ball!

UF vs JV The Gators take on Jacksonville
McKethan Stadium
First pitch at 6:00pm

Wednesday March 21

7:30 am - 8:30 am

UF Clinical & Translational Science Institute
3rd Floor

Good Morning

Registration & Coffee

7:30 am - 8:30 am

UF Clinical & Translational Science Institute
3rd Floor

Standards

Standardization Initiative Breakfast

Discussion Leaders: Tim Garrett, University of Florida and Mike Lee, Milestone Development Services

8:30 am - 10:00 am

UF Clinical & Translational Science Institute
3rd Floor

Symposium Session

Integrating Technologies for High Throughput, Industrialized Drug Discovery

Discussion Leader: John Janiszewski, Pfizer and Abhishek Jha, Elucidata

A High Throughput Metabolomics platform for Drug Discovery
John Janiszewski,Pfizer

The Needle in the Haystack:
Novel Peak ID in Collaborative Science
Drew Jones, New York University

Polly: Where Discovery Happens: The Role of Open Source Algorithms and Data in Drug Discovery
Shefali Lathwal, Elucidata

10:15 am - 11:45 am

UF Clinical & Translational Science Institute
3rd Floor

Symposium Session

Fluxomic and Metabolomic Measurements

Discussion Leader: Matthew Merritt, University of Florida

ß-Lapachone Treatment Interrupts TCA Cycle Flux in NQO1+ Cancer Cell
Matthew Merritt, University of Florida

CA-IX and its Effect on Metabolism and Metastasis
Shonagh Russell, Moffitt Cancer Center

Analytical and Computational Approaches for Metabolic Flux Analysis in Liver
Stanislaw Deja, UT Southwestern Medical Center

12:00 pm - 1:30 pm

UF Clinical & Translational Science Institute
3rd Floor

Lunch, Vendor Spotlight & Poster Review

Novel Approaches to Global Lipidomic Profiling: Redefining Analytical Specificity

Paul Baker, Global Lipidomics Applications Manager, SCIEX

Lunch served in lobby. Join the session, then mix and mingle with our vendors and poster authors

1:30 pm - 3:15 pm

UF Clinical & Translational Science Institute
3rd Floor

Vendor Session

Vendors Meet Customers

Discussion Leader: Alla Kloss, Sanofi

Solutions to Maximize Accuracy, Precision and Coverage in Metabolomics
Suraj Dhungana, David Heywood, and Jimmy Yuk
Waters Corporation

Be on Point in Targeted Metabolic and Lipid Profiling Using the AbsoluteIDQ p400 HR Kit for the Q Exactive MS
Amanda Souza, Thermo Fisher Scientific

Microflow Chromatography Provides Improved Sensitivity and Coverage of Polar Metabolites for Targeted Metabolomics
Matthew Skaley, Ken Jones, SCIEX

Probing Metabolism:
Enabling Pathway-Based Targeted Analysis
Greg N. Bartosiewicz, Agilent

3:15 pm - 4:45 pm

UF Clinical & Translational Science Institute
3rd Floor

Symposium Session

Clinical Applications of Metabolomics

Discussion Leaders: Gustavo Maegawa, University of Florida and Stephan Kang, Intero Life Sciences

Galaxy Enterprise: Explore Next Generation Open Source-Based Integrative Bioinformatics for Multi-Omics
Stephan Kang, Intero Life Sciences

To Be Announced
Cheryl Lee Garganta, University of Florida

4:45 pm - 5:45 pm

UF Clinical & Translational Science Institute
3rd Floor

Graduate Student Workshop

Mentors

Don Chace, Medolac Laboratories
Paul Corcoran, McKinley Scientific
Gabriele Cruciani, University of Perugia
Steve Fannin, Bruker Daltonics
Todd Gillespie, Eli Lilly & Company
Faith Hays, Shimadzu
David Heywood, Waters Corporation
Eugene Inman, Eli Lilly and Company (Ret)
John Janiszewski, Pfizer
Alla Kloss, Genzyme
Yutai Li, Merck
Carla Marshall-Waggett, New Objective
Nalini Sadagopan, Agilent Technologies
Martin Steel, McKinley Scientific
Helena Svobodova, New Objective
Jeremiah Tipton, BioTech & OMICSx Solutions, LLC
Baljit Ubhi, SCIEX
Roy Vaz, Sanofi
Richard Yost, University of Florida

5:45 pm

UF Clinical & Translational Science Institute
3rd Floor

ADJOURN

Closing Remarks

Tim Garrett, University of Florida
Mike Lee, Milestone Development Services